344 



OBSERVATIONS ON THE NITROGENOUS 



Other Experiments. Quinine is reported by various authors * 

 to diminish the excretion of uric acid in man. We have tried 

 one experiment to determine the influence of this alkaloid on 

 uric acid and allantoin output in the cat after pancreas feeding. 



EXPERIMENT VH. 



Two cats were employed. The quinine sulphate was administered in small 

 gelatin capsules. 



It will be seen that the increase in uric acid output here 

 observed falls considerably below that seen in other experi- 

 ments (Exp's III, IV, V) with pancreas feeding. It is 

 scarcely to be assumed that the effects observed are entirely 

 due to deficient digestion and absorption of the material in- 

 gested. Allantoin was not detected in this urine after pan- 

 creas feeding ; this single experiment can, however, scarcely 

 justify any far-reaching conclusions. The same statement 

 applies to another experiment in which tannic acid was given 

 in relatively large doses to cats, in view of the current state- 

 ments regarding the excretion of allantoin in man under such 

 conditions.! No allantoin was found in the urine, and the 

 uric acid output was apparently not modified in any way. 



We have tried to repeat the experiments of Borissow J rela- 

 tive to allantoin excretion in dogs after subcutaneous injec- 

 tions of hydrazine sulphate. The symptoms observed in cats 



* Cf . Thomas, Neubauer und Vogel's Analyse des Earns, 9te Auflage, 1890 

 p. 246 ; Bohland, Miinchner medicinische Wochenschrif t, 1899, xlvi, No. 16 ; 

 Cushny, Pharmacology and Therapeutics, 1899, p. 352. 



t Cf. Anschiitz, T. Richter's Organische Chemie, 1897, i, p. 335; also 

 Bohland, loc. cit 



t Borissow, Zeitschrift fur physiol. Chemie, 1894, xix, p. 499. 



