ANTITOXINS 19 



tate (globulins, nucleo-proteids, etc.) is treated with 

 saturated sodium chloride solution, practically all 

 the antitoxic fraction passes into solution. 



This author has recently studied the possibility 

 of differentiating other antibodies by means of 

 their precipitation characteristics. He believes that 

 a differentiation of the antibodies into those pre- 

 cipitated with the pseudo globulins and with the 

 euglobulin fractions, according to the Hofmeister 

 classification, is based on a misconception of the 

 application of ammonium sulphate in separating 

 proteids by their precipitation characters. While 

 there seem to be some differences in the dis- 

 tribution of the antibodies in individual specific 

 sera in comparative experiments, this is not so 

 absolute as maintained by Pick * and others. Gib- 

 son's work on the fractionating of poly agglutina- 

 tive serum shows that no separation of the several 

 antibodies developed in an individual serum is 

 possible. In the case of antitoxic sera both Gibson 

 and Ledingham find that in goat serum the antitoxin 

 is not invariably associated with the euglobulin 

 fraction as maintained by Pick, but shows the same 

 solubilities as that in horse serum. 



Toxins and other Poisonous Cell Derivatives, in 

 General. Soon after bacteriology had demon- 

 strated the etiological connection between bacteria 

 and disease, the conviction gained ground that it 



1 Pick, Beitrage z. chera. Physiol. u. Pathol., Vol. i, 1901. 



