CYTOTOXINS 123 



von Dungern showed that it was possible to produce 

 an antiepithelial serum by treating animals with 

 the ciliated tracheal epithelium of oxen. This 

 serum was rapidly destructive for this particular 

 kind of epithelium, but it contained also a specific 

 haemolytic body just as was the case in the sper- 

 motoxic serum, and for the same reasons. This 

 antiepithelial serum aroused considerable interest 

 since it indicated the possibility of producing sera 

 which were cytotoxic for certain varieties of epi- 

 thelial cells, especially those of pathological origin, 

 as carcinoma. The numerous experiments made 

 in this direction failed however to produce the 

 desired results. Owing to the extensive distribu- 

 tion of common receptors the antisera were found 

 to exhibit quite general properties and to lack 

 that degree of cell specificity, essential for practical 

 purposes. 



Cytotoxins by the Use of Nucleo-Proteids. --In 

 order to prevent the adventitious formation of 

 those bodies resulting from impure methods of 

 immunization, and also in the hope of obtaining 

 greater specificity, a few investigators have utilized 

 the nucleo-proteids of the cell for immunization. 

 This method seems to have been tried first by 

 Marrassini in 1903, but with indifferent results. 

 In 1905 Beebe * published an extensive study along 



1 S. P. Beebe, Cytotoxic Serum Produced by the Injection 

 of Nucleo-Proteids, Journ. Exper ? Medicine, Vol vii, 1905. 



