ADIPOSE TISSUE. 



307 



4. Fat-cells containing 

 crystals of margaric acid, 

 with a drop of fat; or which 

 are entirely filled with the 

 former. 



The varieties just men- 

 tioned are represented by 

 Fig. 192 ; and in all of them 

 the nucleus and nucleolus 

 become very distinct. 



5. Wedl adds another 

 variety, in which the fat 

 is subdivided into a multi- 

 tude of globules, often group- 

 ed around a lighter-colored 



Fig. 192. 



Atrophied fat-cells from the subcutaneous areolar tis - 

 sue of an aged and much-emaciatedperson. a. Fat-cell 

 shrunken, with crumhling, dark brownish-yellow con- 

 tents ; beneath it one of lighter color, with crystals ra- 

 diating towards the border. 6. An atrophied pigmented 



Space (serum). In many Of fat-cell in apposition with one in the normal condition. 



these Cases the Cell-mem- c - Cells filled with a serous fluid, and presenting in their 



contents well-marked circles (fat-globules in suspension), 

 and delicate, oval, simple or double granules (nuclei). 

 d. Cells containing serum, and whose walls are lami 

 nated. Magnified 350 diameters. (Wedl.) 



Fig. 193. 



a 



branes are no longer visible, 

 they having doubtless been 

 dissolved ; and no vestige 

 of the nucleus can be per- 

 ceived. He also finds that the cell-membrane is thickened in some 

 cases of atrophy of the cell-con- 

 tents, several concentric layers 

 being visible on its inner aspect. 

 These two conditions are shown 

 by Fig. 193, where three normal 

 fat-cells are also added, for the 

 sake of comparison. 



Remarks. Emaciation occurs in 

 almost all chronic, and in many 

 acute diseases. It is especially 

 marked before death by tubercu- 

 losis and by dropsy. In some cases 

 of the latter, the fat of the adipose 

 tissue entirely disappears, except 

 around the heart, and serum takes 

 its place in the adipose cells, as has 

 been explained. It is, however, 

 a singular fact that even phthisis 

 generally produces little or no ema- 

 ciation (even though the structure 

 of the lungs is in a great measure 

 destroyed), provided the liver is also 

 at the same time diseased; especially 

 if from stearosis, or the "nutmeg 

 liver," as it is called. In tubercu- 



Atrophied adipose tissue from the capsuie 

 of a gelatinous sarcoma, a, a. Eows of atro- 

 phied fat-globules, for the most part without 

 any cell-membrane, b. Groups of normal fat- 

 cells accompanying the above, c. Enlarge- 

 ments and bifurcate division of the elastic 

 fibres running among the rarefied fat-cells. 

 Magnified 350 diameters. (Wedl.) 



