MUCOUS MEMBRANE OF THE LARGE INTESTINE. 531 



Portion of one of the patches of Peyer's glands, 

 from the end of the ilium ; moderately magnified. 

 The villi and Lieberkiihn's glands are also displayed. 



follicle being surrounded by the apertures of Lieberkiihn's glands, 



6 to 10 in number, as shown 



by Fig. 861. Fig. 361. 



We have as yet no certain 

 knowledge of the functions of 

 the closed follicles of the small 

 intestine. They become ulcer- 

 ated in typhoid fever, and are 

 subject to various other patho- 

 logical conditions. 



3. Mucous Membrane of the 

 Large Intestine. 



This agrees mainly in struc- 

 ture with the mucous mem- 

 brane of the small intestine. 

 Its peculiarities, therefore, will 

 alone be specified. It presents 



no villi, but, aside from occasional wart-like elevations, it is level 

 and smooth. The muscular layer is difficult to detect, except in the 

 mucous membrane of the rectum. 



The glands of the large intestine are: 1. Lieberkiihn's glands, 

 precisely resembling those of the small intestine, except that they 

 are longer and broader, to cor- 

 respond with the greater thick- 

 ness of the membrane (4^ to 

 fa of an inch, by T J ? to 54 - D ). 

 They are distributed over the 

 whole surface from the ileo- 

 csecal valve to the anus. 2. 

 The solitary closed follicles are 

 very frequent in the colon and 

 rectum, and usually more abun- 

 dant in the latter than in the 

 small intestine. They are larg- 

 er than in the latter locality 



(y'g tO even J- Of an inch in dia- Solitary follicle from the colon of a child, a. 

 \ -, i n i Lieberkiihn's glands. &. Muscular layer of the mu- 

 meter), and Upon each Of the cous membrane. c . Submucous tissue, d. Trans- 

 little prominences tO which the versemuscu lar fibres, e. Serous membrane. /. De- 

 . . pression of mucous membrane above the follicles 

 follicles give rise there IS a g. Magnified 45 diameters. (KiMiker.) 



Fig. 362. 



