344 



DUCTLESS GLANDS. 



to move she could take walks as long as 10 kilometers without 

 much effort. At the same time her disposition changed, became 

 " sour," and everything annoyed her. In endeavoring to counter- 

 act the feeling of cold that the warmest clothing would not allay, 

 she would sit near enough to the open hearth to burn her limbs. 



These signs of intellectual apathy were accompanied by physical 

 symptoms. The skin became pale and the face swollen, losing its 

 oval shape and assuming the aspect of a full moon, symptoms so 

 well described by Gull in his first observations. The swelling 

 extended to the limbs and body, becoming hard and resisting, not 



FIGS. 184, 185. Illustrating Nicholson's article on thyroid treatment in a cretin 

 (Arch, of Ped., June, 1900). Fig. 184, before treatment ; Fig. 185, after treatment. 



presenting the characteristic pitting of edema. The skin lost its 

 softness and the trunk and limbs were affected with ichthyosis. 

 The hair remained long and silky. There was no change in the 

 nails. The development of the teeth was arrested, these being 

 short, as if buried in fungous gums from which emerged only the 

 extremities of teeth. This was more noticeable in the superior 

 maxilla. The child was weighed but, unfortunately, the exact 

 figures were lost. They were, however, very high for a child of 

 her age. Since two years there has been a complete arrest of 

 growth. Her height was about 4 feet 2-J- inches. 



