122 THE PATHOGENIC MICROCOCCL 



guinea-pigs. Dogs and rabbits are immune. Intrapleural 

 injections in susceptible' animals result in a decided pleuritic 

 effusion with formation of fibrinous membranes, intense con- 

 gestion of the lungs on the injected side, great enlargement 

 of the spleen, and general involvement of the blood (septi- 

 caemia) and internal organs, the bacillus being found every- 

 where. 



IV. Bacillus of Rhinoscleroma. 



The bacillus of rhino scleroma discovered by von Frisch in 

 1882 resembles Friedlaender's bacillus in many particulars. 

 It is Gram negative, however, and only moderately pathogenic 

 for many animals which are markedly affected by B. Fried- 

 lander. 



Pathogenesis. In man a granulomatous inflammatory affec- 

 tion, occurring usually at the outer edge of the anterior nares 

 or upon the mucous membrane of the larynx, pharynx, mouth, 

 or nose, is caused by these bacilli. 



Ozaena. A fetid nasal catarrh has been found to have 

 always associated with it a bacillus resembling in nearly 

 every characteristic the bacillus of Friedlander, and believed 

 by many observers to be an atypical form of same. 



EPIDEMIC CEREBROSPINAL MENINGITIS. 



V. Diplococcus Intracellularis Meningitidis. 



This organism was discovered by Weichselbaum, in 1887, 

 in pus-cells (polymorphonuclear leucocytes) of the cerebro- 

 spinal exudate of cases of epidemic cerebrospinal meningitis. 



Morphology. The micrococcus occurs in bunches or in 

 chains of three or four elements, the elements in the chain 

 showing marked variation in size. Stains with all the anilin 

 dyes and is decolorized by Gram's method. It shows marked 

 variation of the different elements in their power of taking 

 color, some elements being deeply stained, others scarcely 

 at all. 



To obtain cultures from man of this bacillus, what is known 

 as lumbar puncture of the spine must be made. The patient 



