ASIATIC CHOLERA. 187 



QUESTIONS. 



When and by whom was the Bacillus coli communis discovered ? 



When* is it found in the body in health? In pathological conditions? 



What pathological conditions are found to be due to the presence of this 

 microorganism? 



Where is it found outside the human body? 



Describe the lint-illus coli communis. 



I l<>\v do its flagella compare with those of the typhoid bacillus ? 



How is it stained ? 



How does it behave in reference to oxygen ? 



What is peculiar about its motility ? 



How does it grow on artificial media and at what temperature? 



What is its thermal death-point? 



What is the effect of cold ? 



How does it grow in bouillon ? On gelatin? Onlactose-litmus-agar? On 

 potato? In milk? In Donovan's peptone solution ? 



What is the effect of intraperitoueal and intravascular inoculations in 

 animals? 



What lesions are found at the autopsy ? 



What lesions are produced by subcutaneous inoculation ? By intrapleural 

 inoculation ? 



What is the Bacillus proteus vulgaris? Its morphology? Biologic char- 

 acter ? Pathogenesis ? 



CHAPTER XIX. 



ASIATIC CHOLERA. 

 Spirillum Cholerse Asiaticae (Comma Bacillus). 



History. In the Cholera Congress at Berlin, 1884, Koch 

 made the announcement that he had been able to isolate from 

 the intestinal dejecta of cholera patients a microorganism 

 which he believed to be the cause of the disease. His experi- 

 ments were carried out in a number of cholera-infested 

 places and on a large number of patients. His conclusions, 

 though very much questioned at the time, are to-day accepted 

 by all, and his SptriUum cholcrcc Asiaticce, more commonly 

 known as the comma bacillus, is recognized as the etiological 

 factor in Asiatic cholera. 



Morphology. This microorganism belongs to the class of 

 spirilla called by some authorities vibrios. 



It is found in the secretions of cholera patients and in cult- 



