HOG CHOLERA. 201 



involvement of the lymphatic glands, and are also followed 

 by effusion in the serous cavities. 



By alkalinizing the secretions of the stomach, animals have 

 been infected by feeding with the bacillus, and in those ani- 

 mals lesions very much resembling the disease in man have 

 been reproduced, and pure cultures of the bacillus obtained 

 from the secretions of the intestines. 



Both toxins and endotoxins have been demonstrated in 

 cultures of B. dysenteric, and antitoxins have been demon- 

 strated in immune animals. 



That the poison is in the cell-body of the Bacillus dysen- 

 teries, and is not a secretion of the cells, is demonstrated by 

 the fact that by heating cultures to a temperature above 

 60 C., which kills the bacilli, does not seem to have any 

 effect on the activity of the poison. 



Protective inoculations in animals have been performed with 

 positive results, and the serum of immunized animals has 

 been found to possess the power of agglutination, and to be in 

 some degree both protective and curative. 



HOG CHOLERA. 

 Bacillus Sui Pestifer. 



History. In the dejecta of hogs affected with cholera 

 Salmon and Smith have succeeded in isolating a bacillus 

 which they found to be the specific cause of this disease. 



Morphology. It is a short, thick rod, 1.20 to 1.50 mikrons 

 in length, and 0.6 to 0.7 mikron in breadth, actively motile, 

 containing flagella, stains by all the anilin dyes, but not by 

 Gram's method. 



Biologic Characters. It is aerobic and grows in all the cult- 

 ure-media. Its growth on gelatin is visible in from twenty- 

 four to forty-eight hours ; the colonies appear irregularly 

 round and the gelatin is not liquefied. On agar-agar the 

 colonies are translucent and rather circumscribed. Upon 

 potato the colonies are yellow. Bouillon is clouded and a 

 thin surface growth may be observed. In milk it does not 

 generate acids and does not coagulate it. 



