PHYSIOLOGY. 



the increase is due to augmented production of heat. I have also 

 shown in the cat that at the juncture of the suprasylvian and post- 

 sylvian fissures is another center whose removal is followed by an 

 increase of temperature. This has been confirmed by White. 



The increased heat-production after injury to the Sylvian and 

 cruciate centers, the fall to normal, and the subsequent rise in some 

 cases indicate that there is a conflict between these centers and those 

 that lie beneath in an effort to gain the mastery. This state of 

 things is seen in the temperature of patients afflicted with fever. 



Puncture, like fever poison, excites the thermogenic centers. 

 Antipyretics act as sedatives to them and so reduce their excitability. 



Albumoses, peptones, skatol, guanine, and neurin have been shown 

 by Ott to produce fever. 



ft**** 



Fig. 185. Curves of Temperature and Respiration when Cortex is 

 Removed and the Animal is Artificially Heated. 



Dr. W. Hale White reports a case in which a bullet from a pistol 

 caused an injury of the anterior extremity of the middle lobe of the 

 right hemisphere and also the third frontal convolution, which was 

 followed by a temperature of 104.4 F. in less than twelve hours 

 after the accident. 



Dr. Page also reported a case of depressed fracture of the skull 

 which was about the posterior part of the temporo-sphenoidal lobe 

 and which was followed by a temperature of 105 F. This tempera- 

 ture fell after trephining, and it did not rise again. Fig. 184 shows 

 the position of these lesions in man, and they correspond roughly 

 to the position of the cruciate and Sylvian centers in the cat. 



THEBMOLYTIC CENTERS. These centers include the cooling 



