Cloudy SiccUijig. 



191 



This process, known as cloudy srvelliiig, albuiiiiiioiis turbidity 

 or albuminous degeneration, first described by Virchow, occurs 

 principally as a result of toxic influences, both definite poisons 

 (phosphorus, arsenic) and the toxines of infectious processes 

 (diphtheria, septicaemia), and, too, from autointoxication from in- 

 flammatory changes. It may be regarded as an expression of dis- 

 turbance of metabolism caused by such toxic action, with impair- 





A 



Fig. 22. 

 A, Cloudy sv.-elling-; B, Complete degenei-- 

 ation of striated muscle fibres. In 

 B the middle fibre is normal, that to 

 the left in early, and that to the 

 right in advanced degeneration; 

 X 250. (After Perls.) 



m 



Fig 23. 

 Muscle of horse (htemoglobin- 

 aemia, 7 hours after the at- 

 tack); a. normal fibre; b, tur- 

 bid and granular fibre; c, 

 hyaline degenerated fibre. 

 (After Zschokke.) 



ment of the elaboration of the nutrient matter appropriated b\ 

 the cells. Either the protoplasm is incapable of assimilating the 

 albuminous bodies brought to it and they therefore accumulate m 

 undissolved condition; or, as Mrchow assumed, the cell is in a 

 condition of metabolic irritation in which there occurs an ex- 

 cessive separation of its albumens ; or it is a beginning cellular dis- 

 integration with formation of modified albumens in the tissue, 

 which are with difficulty soluble. [To a certain extent it seems 



