(jlvco_<:;cnic J n/illralioii : ^Imyloid i'linni:;c. 



205 



Glycogenic Infiltration. 



The glycogen which is physioloo-ically stored uj) in the liver 

 and which is also met in nuiscle, kidneys, uterus, placenta, cartilage, 

 squamous epithelium and in all of the organs of the foetus, may, 

 when circulating in abnormal amount in the blood (diabetes mel- 

 litus) be found in still cither cells, being present in considerable 

 proportions in such circumstances in the leucocytes and renal 

 epithelial cells. It is also found in pus corpuscles in supourative 

 aflfections, and in tumors of embryonic derivation the cells con- 

 tain glycogen. This C( au- 

 dition can scarcely be re- 

 garded as a special degenera- 

 tion, as the glycogen-bearing 

 cells show no other features 

 of alteration. The glycogen 

 exists in the cells merely 

 in the form of globules of 

 larger or smaller size, clumps 

 or granules, staining l)rown 

 with iodine and readily solu- 

 ble in water (or saliva). 



[The condition known as 

 iodophilia, met typically in 

 septic conditions, is due to 

 the presence in the leuco- 

 cytes of these iodine staining 

 granules of glycogen. This 

 condition is demonstrable b\ 



making films of blocd from such cases ; these, while still moist, 

 being allowed to dry over iodine crystals.] 



The condition is probably only an unusual metabolism, an ex- 

 ceptionally rich glycogen infiltration, in which, })ossibly, as sug- 

 gested by Ehrlich, the glycogen was uniformly distributed in the 

 living cells and separated in drops and lumps only as a jxist- 

 mortem phenomenon. 



Fig. 30. 



Olvciigt'uic infiltration of (lie livei- cells; 

 X 1,000. (After Thoma.) 



Amyloid Degeneration. 



The name amyloid (aniylimi, starch; e/5os . nature of) was ap- 

 plied by \'irchow to a substance which gives a color reaction 

 when treated with iodine and sulphuric acid somewhat similar 



