268 



tnflmnmation. 



of proliferation being indicated by the appearance of mitotic 

 changes. After conclusion of mitosis the cellular division takes 

 place, the protoplasm also increasing in volume. The young cells 

 arising from this proliferation persist in part in the inflamed tissue, 

 and after the formation of an intercellular substance constitute an 

 inflanuuatory embryonic tissue, made up of fibroblasts and angio- 

 plasts, which serves the purpose of restoration of the original lesion 

 (cf. Regeneration, p. 237). In part these cells disappear, and they 

 may perhaps exhibit motile activity. A number of the proliferating 





Fig. 50. 

 Inflammatory focus in kidrey of calf, sliowing cellular infiltration. 



connective tissue cells and endothelial cells are sometimes changed 

 by direct nuclear division into multi-nucleated giant cells. The forma- 

 tion of these giant cells is by some supposed to be due to a chemo- 

 tactic influence bringing a number of cells together and causing 

 their fusion ; another suggestion is that the cause of the inflam- 

 matory change has in some way disturbed the protoplasm of a cell 

 so as to interfere with division of the cell substance, although 

 nuclear division goes on. This type of cell is met especially in 

 inflammation excited by foreign bodies, about which corpuscular 

 elements the giant cells are found deposited in a manner explain- 



