2^ Im&immtHi/tiom. 



m its (ddfiaaite local Himaitatoooi. Bacterial suppaisi^on. is progressive 

 aaad as aoDOnaii^aaaied by a naacsre or less serere f ■dmle geaeral reac- 

 tkm (om itioe paat of tbiae solsject. 



As it as ©gimaMy pos^Me to abtain a snjjpEuatiTe inflammaticm by 

 aaoeasss ©ff sterille germ-free cnltiarts of t2ie p^-ogenic organisms or 

 fillltinates wMda coanain goiIt "fee metabolic pnodocts of the bacteria, 

 at aaaay tie ac"'^*"-'! tbsl l3ae pjog-eaoic actioai of bacteria is anotiier 



mstottKne ©f _-.- al acbTit}-; am important factor, hovre^-er, being 



ifflne pjreseare ©f ititese Irving organisms wMd3 nraltiply in the tissue. 

 Hae coaac^ati'GBoi ©f smpfraratioaii is tibeT«f ore aaa setiological one. The 

 j(y©geaaac csqgaaaisms exert, aiaparenitlT by -mpaais of tjaeir toxines 

 mlnada aaie •(Si&ised tiiTongli the lissnes, an exfcremelj- strong diemo- 

 tadtic srtimnkis mpom dae lencocites and in tbis ysrsy indiace a greatl}- 

 hacres.S'ed emigiatiom of ttliese c^Hs: at the ^mte time they have an 

 WE^mtaM. Iianiimfiiall irnfliaejaoe tipon the -sralls of the vessels and nerves, 



IS camsimg Ih3"]j>eTaBmia aaad voluminoiis exudatioii, and produce 

 ^sdfaod" "-=*--- -- -' "--^' -T^e tissues irhidi <&€}- involve. 



Tims: power of .. .^--:. -'--: ^:--;-,^. i.. . -jnen and gelatine may be rec- 

 oganizerd am cnltnres of the organism grown in solid gelatine and 

 soOadafied Mood isenmm, tiiese media being dissolved by peptonizing 

 eaazyimes prodimoed by Jlae lacteria. Leber has pointed oat, however, 

 ttiaat iagaaefoctiocEi of tiae tissntes is to some degree dae to the influence 

 ©ff tine eanaigTated leucocytes or a jsrofceolytic enzymt. given off by 

 ItJaese cdDls; for exa mp le, the lifoefaction attending streptococcus in- 

 fedtaonas aairaisit of aaecessit}- he caused by "fee cells, as these organisms 

 do aaot llagsaefy itSae atoove naentioned ' " ~ ' ^ia. 



I^ appeare as a 'dul! 3-ellow, ->.„,... r..-g: ten or graiiish- white 

 ihmid, opagaae aaad creaany, thin and irmlky or more thick like egg- 

 aUBaaaanein, aDOGfirdaaag to l3ae amount of plasma it contains, becoming 

 !re«3dMiHginay or of a caie-S3i-1ait color in case of greater diapedesis 



V- red (Dorpmsdks. It is often mixed with fibrin in the form of 

 ^mmaRH ^ - - . wiuada gives the pus a dough}- consistence 



-' : • ..lemt issrmdaie) aaad fills the tissues with a fine reticulated 



str. ;: - - 



''- :• ■'•'; ."-fscope pus shows great numbers of leucoc}i:es, 

 -• ■ .1 p--j: " " ' '!}-morf'-' ---'•" -ar t\-pe. showing instead 

 ..: - -~'—j~ '..„_ :. „ ...^5 a r._j;. .tr of nodular Ctectiit and 

 die t:-.:-L; :.::'=^' ^-nd fragmented portions of nucl^ir substance. 

 TBne icomtiimal};^' ' • ; . 'ating leiacoc}'tes, among' which are also mono- 

 aaaadlear t; l - : fs. ar^ sianilar to those found in the blood- In most 

 off jheptm^ aaad C" 'I3- im alL aaecinosis is recognizable because of 



TOirocfear feagaaae' ' and naoire certainly hy the presence of fatt}- 



