Tuberculosis. 



299 



cells. Its deposition, along with the toxine which it produces, 

 causes a reaction on the part of the tissue as about a foreign 

 body, in which, however, the special toxic action of the micro- 

 organism takes part and gives rise to coagulation necrosis. 

 The first evidence of reaction as shown by the studies of 



EmboL_ . 



cheesy centre 

 tissue ; X 00 



Vlg. 02. 



lie miliary tubercle from lung of liorse (after Johne) ; a. giant cells: h, 

 lieesy centre: r, small as yet not caseated tubercle; cl, surrounding pulnionai-y 

 issue ; X 00. 



Baumgarten, Johne and others is the appearance of karyokinetic 

 figures in the fixed connective tissue cells and endothelial cells, 

 and side by side with this an increase of the latter. The prolifer- 

 ating fibroblasts, among which usually giant cells occur, surround 



the tubercle bacilli ; and further out 



immigrating leucocytes 



