314 



Specific Inflammations. 



mmm^^W} 





in the lymph spaces and therefore open to lymph convection, is dis- 

 seminated in the vicinity of the primary focus, passes along the 

 lymph vessels and into the blood ; and new points of deposition and 

 new foci of the disease occur locally and metastatically. The bacilli 

 are also carried by currents of secretion and may lodge in a fresh 

 position on the mucous membrane, here again to give rise to new 

 colonies, as where they are carried from the lungs to the larynx 



and pharynx. The metabolic prod- 

 ucts of the organisms, developing in 

 the system, by their toxic influences 

 occasion fever and wasting. 



The visible anatomical changes 

 of the disease vary considerably with 

 the virulence of the affection and the 

 tissue predisposition of the particu- 

 lar kind of animal. The principal 

 types are the glanders nodules, 

 glanders abscesses, gla)iders indu- 

 rations and glanders infiltrations. 



Glanders nodules, developing 

 niainl}- in the lungs and parenchyma- 

 tous organs, appear as grayish-white, 

 semitransparent. opalescent, rounded 

 ])rominences or deposits ranging from 

 the size of a grain of sand to that 

 of a pea, their central portion break- 

 ing down into a yellowish-gray, 

 purulent or dry cheesy material. In 

 the lung they are often surrounded 

 by a dark red area. The glanders 

 ulcers present themselves on the mu- 

 cous membranes of the respiratory 

 tract as shallow or deep lesions, varying from the size of a lentil 

 to that of a silver dollar ; the loss of substance giving the mucous 

 membrane an appearance of being eaten or gnawed. The larger 

 ones have thick, wall-like, eroded margins. These ulcers have a 

 bacon-like gray color, with the bordering mucous membrane often 

 dark red and hyperaemic, bleeding on the least provocation. There 

 are usually large numbers upon an affected mucous membrane. 

 The glanders ulcers of the skin range from the size of a lentil to 

 that of a half dollar, are of a dirty grayish-red color, covered with 



Fig. 76. 



Glanders induration of the uasal 



mucous memibrane of tbe 



horse. 



