358 Tumors. 



cut surface a fibrous or striated appearance, of a reddish-gray or 

 pale gray color. Especially the leiomyomata growing from the 

 uterus and hanging to this organ in the peritoneal sac, may attain 

 enormous size, possibly as large as a well filled horse's stomach, 

 weighing from thirteen to thirty-six, to one hundred kilograms. 



The smooth muscle fibres, easily recognized by their long 

 fusiform shape and rod-shaped nuclei, are arranged parallel to 

 one another in bundles interlacing in every direction with each 

 other in confused manner. In sections the fascicles are found 

 cut longitudinally, obliquely and transversely, and between these 

 the vascular connective tissue may be 'observed in variable 

 amount as clearer threads. In pedunculated examples where the 

 myomata have in consequence been subject to twisting, circu- 

 latory disturbances are often determined, as results of which 

 congestive haemorrhages, cedematous appearance, anaemic necroses 

 and fatty degeneration may take place in the tumor mass. 



In man epithelial inclusions and hollow tubules have been 

 noted in the myomata of the genital organs, this histological 

 feature giving support to the view that the myoma in this 

 situation is related to embryonal disturbances which have occa- 

 sioned misplacement and isolation of portions of the Wolffian 

 body or of the Miillerian ducts (adenomyomata). 



Leiomyomata are usually single primary growths [in human 

 beings they are often multiple], and give rise to harm only 

 by their volume. They are not recurrent tumors [and are not 

 metastatic] 



Neuromata and Gliomata. 



A neuroma, or nervous tissue tumor, strictly speaking must 

 be made up of nerve fibres or gangliomic cells in luxuriant prolif- 

 eration, accompanied by a supporting framework and by bloodves- 

 sels. If we exclude the terminal thickenings of nerve stumps 

 occasionally occurring after neurotomy, the so-called amputation 

 neuromata (v., p. 250), from the list of true tumors (because their 

 growth ceases after a time), it may be said that the formation of 

 true neuromata in animals has as yet never been certainly proved 

 to occur. Even in man but few instances of this type of neoplasm 

 are known, situated in the sympathetic area (especially coeliac gan- 

 glion and pelvic plexus), as nodes ranging up to the size of a 

 child's head. 



The growths summarily designated by the name neuroma in 



