Lymphoma. 



375 



color, which may be either diffuse or present an irregular mottling. 

 The infiltration follows along the lymph spaces of the connective 

 tissue, especially along the perivascular lymph channels, and may 

 lead by special local accumulations of the tumor cells to the pro- 

 duction of new tumor-like nodes as well. The lymphosarcomatous 

 cells, however, also penetrate into the blood vessels, and by con- 



Fig. Ill 



Multiple lymphomata in liver of hog (general progressive lumphomatosis). 



vection may occasion metastatic nodules in various organs, especially 

 in their lymphatic structures. The fact that the lymph glands in 

 order of position undergo enlargement one after another, and that 

 the metastases are principally located in the lymphatic structures, 

 may, it is thought, be due to chemotactic influences of related 

 type's of cells (Ribbert). It may be that the lymphosarcoma cells 



