390 



Tumors. 



in size or may be present in a greater number of layers, and its 

 secretion may be of a degenerative character (for example, from 

 the assumption of mucoid change by the adenomatous cells or 

 their destruction by excessive fat production). The connective 

 tissue, which in direct limiting relations to the epithelium forms 

 its tunica propria and in lobulated types of gland tissue forms a 

 meshwork of septa, is often developed in special excess, forming 

 denseh' fibrous sclerotic trabecula which embrace the glandu- 

 lar ducts in compact circular investing bands {adenofibronia 

 pcricanalicularc) or form club-shaped or finger-like projections, 

 stretching the adenomatous lumina, increasing the surface of 

 the glandular canals and extending into the latter as villous 

 papillae (adcuofibroiita iiitracanaliciilarc, adciiojiia papUUfcnim). 



/ 



/ 



W 



Fig. 117. 



Adenoma flavnm of liver of cow. 



The tubular or vesicular spaces of the adenoma, by continu- 

 ous and progressive formation of hollow buds lined with epi- 

 thelium, become more and more branched and more irregular than 

 in the normal gland; and by this intricate projection of epithelial- 

 covered connective tissue processes into their interior become 

 changed into tortuous passages and openings, which may become 

 quite large. The cut surface of an adenoma ma}^ in this way 

 come to closely resemble a section through a head of cabbage, 

 in which spaces are to be seen between the layers of leaves. As 

 these adenomata are completely isolated new grow^ths and their 



