OF VETERINARY MEDICINE. 159 



of five bitten by rabid animals develops the disease. So far as 

 the specific virus is concerned, we do not know much about it, 

 but the agent must be large for it can be filtered out from the 

 saliva. The so-called Negri bodies are a phenomenon of this 

 disease. In 1903 Negri discovered the small bodies in the nervous 

 tissues of rabid animals. They can be seen under the scope in 

 the form of little granular oval or round masses which stain red. 

 They are found in the substance of the brain, especially in the 

 horn of Ammon. Investigation of these bodies is being con- 

 ducted in many laboratories and all reports do not agree as to 

 the importance of these bodies from a diagnostic standpoint. 

 They have been found in animals not diagnosed as having rabies, 

 but such diagnosis was not positive. 



Prof. Negri, Dr. Lagorio (Chicago), and Dr. Frothingham 

 (Boston) have done much work on the subject of rabies. Dr. 

 Frothingham claims that these bodies are a positive evidence of 

 rabies. 



So far as the deprivation of water is concerned, any animal 

 will develop a fever when deprived of water. Statistics prove 

 that we have more rabies in the fall and winter than in the 

 summer and the temperature has nothing to do with it. 



The period of incubation may be as short as a week, and it 

 runs an indefinite length of time. Rabies may be traced to a 

 bite 6 months past. The incubation period averages 28-35 days. 

 The periods are the same in all animals. 



Semeiology. — Horse. The first thing noticed is nervousness. 

 There is an unnatural twitching of the muscles of the face and 

 the patient is irritable, inclined to bite his attendant. He drinks 

 slowly and on the second day cannot drink at all. He shakes his 

 head, breaks the bucket, etc., and does not eat because of the par- 

 alysis of the muscles of deglutition. The horse grows constantly 

 more restless and has spasmodic fits of kicking; makes attempts 

 to bite, but does not really do so. 



According to the severity of the attack paralysis sets in 

 sooner or later and the animal staggers until he goes down in a 

 fit of unconsciousness. 



The bitten part seems to itch and the horse rubs his wound 

 against the stall. If the wound is on a leg, the animal nibbles the 



