28 PROTEIDS. 



Pure paraglobulin is insoluble in water. If dissolved in a 

 m.i/tii'm.al anwunt of alkali it is precipitated by "03 to '5 p.c. of 

 JiaQl. On the addition of more than *5 p.c. of the salt it oes 



again into_solution and does not begin to be reprecipitated on the 

 addition of more salt until at, least 20 p.c. NaCJ. has been added. 

 It is not completely precipitated by saturation of its solutions 

 with NaCl (Hammarsten). Its dilute saline solutions .coagulate 

 on heating to 75 . 1 Dissolved in dilute solutions of NaCl or 

 MgS0 4 its specific rotatory power is stated to be (a) D = 47 '8. 2 



Paraglobulin occjrrs in smaller amounts ( |) in chyle, lymph, 

 and serous fluids. Hammarsten by means of saturation with 

 MgS0 4 was the first to shew that hydrocele fluids frequently 

 contain paraglobulin, thus largely shaking the importance of Al. 

 Schmidt's views as to the part it plays in the process of blood- 

 clotting. 



Globulins which are not regarded as differing essentially from 

 paraglobulin are also stated to occur in urine. 3 



Cell-ylobulins. Halliburton has described under this name 4 some 

 forms of globulin which Qccnr in lymph-corpuscles and may be ex- 

 tracted from them by solutions of sodium-chloride. Of these one, ce1I r 

 glbbulin-q, occurs in minute quantities only and is characterised by 

 coagulating at 48 50. The other, cell-globulin-/?, is more copiously 

 present in the corpuscles and coagulates in dilute saline solutions at 

 75. The latter resembles paraglobulin very closely in properties 

 other than the identity of their temperatures of heat coagulation in 

 dilute saline solution, e. g. precipitability, &c. He considers thaj 

 cell-globulin-/? differs from true paraglobulin, or_ plasma-globulin as 

 he terms it, by possessing the power of hastening the clotting^of di- 

 luted salt- plasma, and he regards^ the so-called 'fibrin-ferment T as^ 

 identical with ^ell-globulin-^ and "arising from the disintegration of 

 leucocytes. 



The proteid constituent of the stroma of red blood-corpuscles con- 

 sists chiefly of a globulin usually regarded as identical with paraglo- 

 bulin, since its saline solutions coagulate at 75 and it is precipitated 

 from the same by saturation with sodium chloride and a current of 

 carbonic anhydride. 5 Halliburton considers it to be identical with 



plied it somewhat differently to Denis. On the use of ammonium sulphate for 

 separating globulins and serum-albumin see Michailow (Russian), Abst. in Malv's 

 Bericht. Bd. xiv., xv. (1884-5), Sn. 7, 157. Pohl, Arch. f. exp. Path. u. Pharm. Ed. 

 xx. (1886), S. 426. 



1 Halliburton, .//. ofPhi/siol. Vol. v. (1883), p. 157. 



2 Fre'de'ricq, Arch, de BioL T. I. (1880), S. 17. Bull. Acad. roi/. de Belgique (2), 

 T. iv. (1880), No. 7. (See Maly's Bericht. 1880, S. 171.) 



3 Lehmaun, Virchow's Arch. Bd. xxxvi. (1866), S. 125. Edlefsen, Arch. f. kiln. 

 Med. Bd. vn. (1870), S. 67. Also Central b. f. med. Wiss. 1870, S. 367. Senator, 

 Virchow's Arch. Bd. LX. (1874), S. 476. Heynsius, Pfliiger's Arch. Bd. ix. (1874), S. 

 526 (foot-note). Fuhry-Snethlage, Arch. Mi'n. Med. Bd. xvn. (1876), S. 418. 



4 Proc. Hoi/. Soc. Vol. XLIV. (1888), p. 255. Jl. of Pfn/swl. Vol. ix. (1888). 

 p. 235. 



5 Hoppe-Seyler, Physiol. Chem. S. 391. Kiihne, Lehrbuch, S. 193. Wooldridge, 

 Arch. f. Phi/siol. Jahrg. 1881, S. 387. Hoppe-Seyler, Zt.f.physiol. Chem. Bd. xm. 

 (1889), S. 477. 



