CHEMICAL BASIS OF THE ANIMAL BOI>\. 



cell-globulin-/?, and arc-mints thus for tin- curlier statements a.s t<. tin- 

 tibrinoplastic properties of tin- stroma-glubulins. 1 



/ 



4. Fibrinogen.- 



f 7 



This globnliq oec-irs in blood-plasma together with para^lolMi- 

 lin Uidaeram^aJiQUpiri. During blood-clotting it is converted 

 ~ " 



Iy7~ir noTentirely, into tibriu (but see below). It is ;dso 

 found in clivle. serous thuds and transudations. more particularly 

 in hydrocele tluids. :: 



In its iji-neral reactions it resembles para^lohulin bnt is 

 markedly distinguished from the latter by tin- following charac- 

 teristics. (1) A* it occurs in plasma 4 or in dilute solutions of 

 sodium chloride (1 5 p.c.), it maculates at ~>~> .")Q^ (2} It is 

 very readily' precipitated by^ the addition of sodium chloii de to 

 its salijir snlutiuj^s until the wlndr contains 10 p.c. NaC'l. whriv- 

 as paraultiliiilin is not appivcial.dv precipitated until at least 



- . 't the sodium salt lias lieen added. 



ii:' Salted jilasma, obtained by Cjintrifu^alisinu blood 

 \vhose _eoa^nlat_ion is ]irevented lv the addition of a certain pn.- 

 ])ortion of mauiiesium sulphate, is nn^ed with aii__e<iual volunif 

 of_a satunited (35\S7 p.c. at 14 C.) solution of sodium chloride; 

 the fibriiiogeu is thus preci])itated while the pin-aul"bulin ivniauis 

 jn sohition. The adhering plasma may ! ivTnoved by washing 

 with a solution of snjiuin p.liloridp, and the fibrino^en finally 

 purified by bein^ several times dissolved in and repiveii'itatrd l, v 

 sodiyju 



Haiiiniar>tfii's statfim-nts as to tin- nature and propt-rt ii-> i.f tiliri- 

 iio<rcn liavi- IM-CII tin- sulijfi-t of inii'-li -ontro\ci>y lu't\\n-n lniiisi-lf. Al. 

 Schmidt, and 



When a fluid containing purified 

 tibnn bv the action of fibrin-ferment, thejmiount ofjj]aiii iojiu^l 



i .//. /'/Vi,/siW. V..]. \. (1*89), p. 532. 



- llamin: 1 psahl. Vol. \ 1. \^.'< BfTtcAl. 



B. 15. I'tluu'-r's Arrh. 15.1. \l\. (1-771. S. I'll . M 



:|; \\\ (1883), S. 437. Maly's />''' MI ( I --'), S. 1 1. Al Nlmii.lt. 

 I'llii-.-r's Arch. H.I. M (1"7-J), S. 4KI;' xj. (1-::.). > Ml! MM (1876), ^ 14 

 " I.i-lm- \ mi .Ifii frrmciit QerinoiuigMneb*ioiuiff0o a ^ 



/ Vol. l\ (I:!), i 



S, :;i:i ; |~- \'..l. i \n ' l.n-lwiu - 



/. L887, S. -J-JI. Zt. /I i: "I. H.I XMV. I- 

 S 174. './/. I'l.if,,..':. \ 1 x 



lla.niniirsten, Maly viu. (I87H). S 



4 Fr.'.l.Tic.]. .\,m. & 



Hull, dr l'Ar,,,l. r..y. </ A'.///"/'/,. I i KH (1H77), No. 7. " Kocherchca nur la coo- 



stitiitinn <lu |il:i.mn:i s.in^nin " I '.in-. 1878. 



' li.iinini' -mi. QMWM, PA jpwi Cktm \'.>1 i p. 41. 



.l;i>i. C/nm. /'/!//... i 



