CHEMICAL BASIS OF THK ANIMAL lioDV. 



remain- of tin- white corpuscles anl the .-tmmata of tin- red l It 

 can only he prepared pure during the chtttiiii; of i-itljej filtered or 

 ceiitrifu^alised iced-plasma oii_aaJjLi|>lasiiia, or by theaction of 

 purilied li Iain-ferment on pure tihrinoi/en. In accordance with 



fibrin as ordinarily obtained lea. :riable amount of 



granular residue which contains phosphorus durini: it- digestion 

 by pepsin. NII -uch residue i- observed \vhni lilnin I'rmu til' 

 jtlasma is di-i'-t'-d \vitli JM-JISJII (set- lclu\v. j. 4'2 ), luit in im otlit-r 



iitial ivxj,,.(-t d-- tin- inn- liln'in diltcr frum tin- ntlin 

 liilirin. a- ordinarily olitaiiu-l. rxhjbits a tilaiut-ntous struc'tinv. 

 tin- riiinjM.nciit threads lu'-s.^sin^ an t'lasticjtv much ^ivatcr 

 that itt' any utln-r kumvn solid )intcid 



It' allowed to firn7 gradually in laryi- maf>, tin- 

 structure is n-'t >n imticralilc. and it ivsriuMrs in this i'urni 

 india-rulilir]- Sucli lunijis of lilirin aiv cajialdc of licin^ split in 

 any direction, and no definite arrangement of paiallel luindle^ oi 



'an lie made nut 



Filirin is insolnhle in \vater jind ,/j'/,it, s^jim. ^..Imioi^ : 

 also ordj^jirily insolnlde in dilute acids (HC1) & their action 



|>lac,- at ordinary tein|)e]'atures and is not prolonged, nit-rely 

 liecoinin^ swollen and transparent in the acid and returning t" 



spinal >tate if the acid i> removed by an ezoeafl "1 Wt1 

 careful addition of an alkali JSyjjro loured action at ordinary 

 tej^})eratuivs. or a shorter action at 40, the jihjiu is profoundly 

 cjian^ed and certain forerunners of the peptones which mayije 

 tinully formed (at 40 J ) n,re ]n-odnced It is similarly insoluble in 

 <|ilute alkalis_and ammonia, hut }':_i^s; j > more readily into solution 

 inj.lu-se rea;ients r if their action is prolonged or the temperature 

 is raised, than i> the case with dilute acids The heha\ i>ur of 

 tihrin towards solutions ( ,f neutral salt- is peculiar and important 

 I ready Maic'd, tihrin pre)>aivd hy simply whipping hlood i- 

 insolulile in dilute saline solutions I'.nt it- -i.luhility is de|H-nd- 

 ent upiin the conditions under which it is separated out from the 

 blood. In accordance \\ith tin-. I Jenis - descrihed three form- of 

 tilirin to which he gave the name- of 1 l-'ihrine . oncivte ll|( ,di 



'_' Fil.iine -lolnilme. :; I-'ii.rme .-oncn-te j.uie. Th- 

 is what \\e now know as ordinary tihrin olitained hy \\hippini; ar- 

 terial hlood (human in Peiii-' \\oiki Tlie -e. ond he ohtained hy 

 the -jii.ntaneoiis clotting of human \eiion- I'lood. and thi- ieadil\ 

 -well- up to a slimy ma-- in 10 ]>.<-. NaCl. The third h- 



i liy 'whijipinu' human venous hloo<l under certain precau- 

 tion-, and found it to he -oluhle in ilil olution h\ 01 

 iwo hour-' treatment with th< W , < t ) ur 

 Hammar.-ten'- pai t ial conlirmat imi of I eni^' -tatement - tli> 

 hut little reason for doubt mi,' the accuracy of so careful 



' Ilaiiiiiiarstc-ii. I'tlu. I ! : NMI (1880), S. 481 ; XXX. (1883), S. 440. 



I : 



