CHEMICAL BASIS "K Tin: ANIMAL I;<>DY. 



during th'- hydration which loads to the formation of JH-J.I. 

 He found al-o further continuation ut' this probability in tin- work 

 of Schut/enb< This, observer, decomposing proteids with 



.icids at 100' ('., came to the conclusion that halt' the proteid 

 molecule is readily decomposable ly the acids, whik- the other 

 hall' is jieculiarly resistent and is obtained in the final products 

 as an extraordinarily indigestible but true proteid, t<> which he 

 gave tlie characteristic name of ' hemiprotein.' Convinced thus 

 of the doulde nature of the proteid molecule. and seeing hut little 

 hope of separating i'roin each other in a mixture the two pep- 

 tones which must presumably ie-uh from the gastric peptoni-a- 

 tion of a proteid, Kuhne endeavoured to establish their exi-tence 

 by trying to discover the primary products intermediate hetween 

 the proteid and the jx-ptones, antipeptone on the one hand and 

 hemipeptone on the other. 3 Iii this his endeavours were at once 

 d liy his being in posses-ion of a large amount of a proteid 

 identical with that first described and carefully examined by 

 r>ence-.lones, and hence called by his name. 4 A renewed exami- 

 nation of this substance revealed that it was capable of <-on- 

 \ei-ion by pepsin into a peptone which was readily further 



nposfd by irypsin.-'' It was j M fact the product intermediate 

 between the original proteid and the hemij>eptone. and to it 

 Kuhne gave the name of hemialbunio.se It now was only i. 

 sary to obtain the corresponding a Ibumose precursor of the anti- 

 peptone, to peptonise this, and shew that the peptone thus obtained 

 would yield no leucin or ty rosin by even prolonged treatment with 

 trypsiu. Tliis Kuhne succeeded in doing by a fractionate.l peptic 



:ion' ; and thu- established his own views, and in don 



shewed how acelllate a.S il whole MeisHlcl'- statement- 



This will be evident from the detailed description of ti 

 products ,,f the decomposition of proteids by prpsin, tr\ p-in, and 

 arid-, which i> given below. The fundamental notion, then, of 

 Kulmc's view i- that an ordinary native albumin or fibrin con- 

 tain- within it-.-lf t \\ residues, \\hi-h h. lively an 



anti-r.-i.liie and a hemi-residuc The iv-ult of eitlier p,-p- 

 tryptic di-e-tion i- U) split up the albumin or fibrin, and to pio- 

 diu-e on the part of the anti-rc<idue ant i]x-ptone. and mi th- 

 of the hemi-roi.lue lnMiii]M-pt<inr. t lie latter being distinguished 

 from the former by its bring su-ceptible ,,f further change by 



, ,,. d. not*M*rm*l. iw. ii,-i,irii, \ i : 



?OC clnm. I'ari-. T XML [1875 , pp. U 



T \\tv. ].i.. j i f. BM Bbd M.I!-. Jot ' IM r. (H 



Tli- naiii.- ' li.-iiiiiM-i.t. ..... ' w:i.s -;i.-ii in ..nli-r L. r..m.-\ the idc* thl 



IHM.I..II.- for.n-.l fr..iu ..... I li:ilf "f tli- .,ripn:il J.r..|,-i,| innlmilf ' :uHi|" 



..tli.-r lian.l tl.at it is llial ("Tin ( |H-|I|<IIH- !ii.'h i' ; 



anv fiirtli.-r .l.TMi,,,H.siii L ' :i''li"ii "f tli" ngtMlU whirli 1-1 I- 11 



, / ; i- : . ,/. t'hrm.U.ri< HI. (I 



1 Kiiliii-. y.t /: I!''"!. 1M. MX. (1S83), S. 209 

 K-.iliuc it. Cliitt.'ii'l-n. /'"/. S. 1T1 



