CHKMir.u. r.AMS OF THE ANIMAL BODY. 179 



which it may he converted by treatment with chlorine or nitric- 

 acid, or still more readily by bromine. 



C 7 H 8 N 4 O 8 + Br 2 = C 6 HN 4 O . HBr -f CH,Br + CO,. 



I' In- latter may be isolated from its hydrobromic acid salt by 

 means of caustic soda. 



5. Hypoxanthin or Sarkin. ( ll^N/t. 



NH CH 



I II 



00 ' N\ 



NH C = N 



(?). 



Closely related to xanthiu and usually occurring witli it in tin- 

 tissues and fluids of the body. It- constitutional formula has not 

 yc-t l>eeii definitely ascertained, but it will probably be found to 

 contain the group N = CH N in the place of one urea residue 

 in xanthiu. 1 On this supposition three formulae are obviously 

 1'o-sil.le, and the correct one has still to be determined. Hypo- 

 xanthin may be obtained from normal muscles, and hence is found 

 in larger amounts in 'extract of meat.' It occurs also in the 

 spleen, liver, and medulla of bones, and in considerable quantity 

 in. the blond - and urine 3 of leukhiemic patients; also in normal 

 urine 4 and in vegetable tissues lupins, 6 malt-seedlings, and 



FlO. 26. Ih I-M\ \\TIIIN--II \ l i: Ml l: \ i l . ' ' .HjN^O AgNO t . 

 (KrukcnU-rg after Kuliiie.) 



It i^ obtained from fluids or tissue extracts by means of tin- 

 processes already mentioned I'm the extraction of xanthin. and 

 is separated from the latter by taking advantage of the slighter 



1 I- -/. ,/. ,-!,. Getell. 18- 



*s.-l. '/.l. f. ph,,itol. Cliriii. IW. v. (1881), S. 267. 



n hc.w'.M Arrl,. \kl cix. (1877), 8. 390. 



4 (,. S:il,.i,,,,ii. Zt. f phi/tiol. Chem. Salkowki, Virchow'f Arch. Bd. L. (1870), 

 S. 195. 



6 Salomon, Verhnnd. d f ,fi V tiol. Gettll. Nor. 12, 1880. Arch. f. Phyiiol. 1881, S. 

 166. 



6 Baginskr, Zt. f. j^siol. Chen Bd. vm. (18834), S. 395. 



