126 IMMUNE SERA 



these lines and described the formation of a nephro- 

 toxic serum which caused albuminuria and acute 

 degeneration of the kidney without changes in 

 the other organs. Albuminuria appeared gene- 

 rally on the fourth or fifth day, increased rapidly 

 in amount, and was accompanied by the excretion 

 of hyaline and granular casts. Subsequently Pearce 

 and Jackson, 1 after a careful experimental study on 

 the production of cytotoxic sera by the injection of 

 nucleo-proteids, conclude " that the results do not 

 support the theory that specific cytotox ! c sera may 

 be developed in this way, but indicate, rather, that 

 such sera have certain mildly toxic properties acting 

 in a general way and affecting especially the principal 

 excretory organ, the kidney." 



1 R. M. Pearce and Holmes Jackson, Journal of Infectious 

 Diseases, Vol. iii, 1906. 



