1 78 IMMUNE SERA 



then thoroughly emulsified in distilled water, using 

 about as much water as the volume of serum orig- 

 inally poured off, and the mixtures allowed to 

 stand for a few hours at 37 C. This more or less 

 autolyzed fluid is used for the injections, and the 

 dose employed varies from 5 to 15 cc., repeated 

 several times. 



Application and Results. In their work, clinical 

 and experimental, Hiss and Zinsser 1 thought they 

 saw little indication of immediate bactericidal 

 power possessed by the leucocyte extract, but that 

 the results pointed rather to a marked power on 

 the part of the extract to reduce the purely tox- 

 semic manifestations in infected subjects. Favorable 

 clinical results have been reported by these authors 

 in cerebrospinal meningitis, lobar pneumonia, 2 and 

 other infections, and while the data are still too 

 scanty to justify definite conclusions as to the 

 value of this treatment, enough has been done to 

 warrant further careful clinical investigations along 

 this line. 



1 Hiss and Zinsser, Journal Med. Research, Vol. xix, Nov., 

 1908. 



2 See also Floyd and Lucas, Journ. Med. Research, VoL 

 xxi, Sept., 1909. 



