H&MOLYSINS. 45 



Coming now to the question as to what part of 

 the cell it is which excites the production of the 

 haemolytic immune body, we find this, according to 

 v. Dungern, to be the stroma of the red cells. If 

 this be so, it must be the stroma which combines 

 with the immune body. Nolf, however, claims 

 that the cell contents are factors in the production 

 of the immune body. So far as concerns the site 

 in the organism where the substances used in immu- 

 nizing find their receptors, this is not known for 

 the haemolytic immune body. For the bacteri- 

 cidal immune bodies of cholera and typhoid, how- 

 ever, we know from the researches of Pfeiffer, Marx, 

 and myself that this is chiefly in the bone marrow 

 as well as in the spleen and lymph bodies. 



Anti-haemolysins : their Nature Anti-complement or 

 Anti-immune Body? A further step in the study 

 of haemolysins is one discovered independently 

 by Ehrlich and Morgenroth on the one hand and 

 Bordet on the other. These authors succeeded in 

 producing an anti-H&molysin. The procedure is 

 closely related to the results gained by immunization 

 against bacterial poisons. A specific haemolysin, 

 one, for example, specific for rabbit blood, de- 

 rived by treating a guinea-pig with rabbit red 

 cells, is highly toxic to rabbits. Injected into the 

 animals intravenously in doses of 5 c.c. it kills the 

 animals acutely, causing intra vitam a solution of 

 the red cells. Such a haemolytic serum, then, acts 

 the same as a bacterial poison, and it is possible to 



