4m 



the National Heart Institute of the National Institutes of Health have 

 put money into special hyperbaric facilities. A fair amount is going on 

 in this area. 



Mr. EoGERS. It is very encouraging, as I understand it. 



Dr. Jacobs. Yes. 



Mr. Rogers. Let us have a rundown on that, too, wiU you, for the 

 record ? 



Dr. Jacobs. All right. 



Mr. Rogers. Thank you very much, Mr. Chairman. 



(The requested information follows :) 



Stjppobt for Hypeebakio MHa)iCAL Research and fob Construction of 

 Hypeebaeic Facilities by the National Institutes of Health 



The National Institutes of Health is either currently providing, or has recently 

 provided, financial support for five projects involving medical research under 

 hyperbaric pressures. It is anticipated that both the facilities and the supported 

 research conducted in them will provide substantial assistance in dealing with 

 the problems of man in the sea. The primary objective of the National Institutes 

 of Health support of these projects, however, is to solve medical problems of 

 man in his normal atmosphere and land environment, particularly to investigate 

 the therapeutic value of hyperbaric oxygen. 



1. duke university 



The National Heart Institute has for some years been providing funds by 

 grant to Duke University to support a program of multidisciplinary investigation 

 of hyperbaric oxygenation. Construction of new and enlarged hyperbaric environ- 

 mental chamber facilities was initiated in 1965 and it is anticipated that active 

 use of the chamber complex will occur early in 1988. 



The environmental facility includes six compartments, each of which can 

 he operated independently of the others. These are : a surgical sphere, with an 

 ■eight atmosphere capability ; a therapeutic chamber and personnel lock both 

 with a capability from eight atmospheres positive to one Torr (equivalent to 

 an altitude of more than 150,000 feet) negative; and a diagnostic chamber, 

 personnel lock and water diving chamber, all capable of withstanding 30 atmos- 

 pheres of pressure (equivalent to a diving descent of 1,000 feet in sea water). 



Research in this new facility will include studiese (1) on the effect of oxygen 

 under high pressure on cerebral blood flow, retinal blood flow, infection, and 

 preservation and rejection of homotransplants ; (2) of the physiology of liquid 

 and dense gas respiration; and (S) on patients with stroke, myocardial infarct 

 tion, shock, congenital heart disease, gas gangrene, and vascular occlusions. 



The National Heart Institute has provided approximately $510,000 for the 

 hyperbaric chamber, and through FY 1967 just less than $1 million to support 

 the operation of the research program. 



The hyperbaric chamber is located in a two-story wing of the large clinical 

 research building for which the Division of Research Facilities and Resources 

 supplied $1,036,984 through a Health Research Facilities grant. 



2, university of PENNSYLVANIA SCHOOL OF MEDICINE 



New environmental research laboratories, partially supported by grant from 

 the National Heart Institute, are being developed at the University of Pennsyl- 

 vania School of Medicine under the leadership of Dr. C. J. Lambertsen. These 

 facilities, although not now completed, should become fully operational during 

 1968. The laboratories include a complete pressure unit with the capacity to 

 simulate any known climate in the world and the range of environmental pressure, 

 temperature, gaseous composition and humidity to be encountered in manned 

 activities from sea level to 150,000 feet of altitude, and from the surface to a 1,600 

 foot depth in sea water. The new chamber system also includes a "wet" diving 

 chamber which, when filled with water, will simulate the high pressure, wet, 

 cold, buoyancy, and dense environment of the deep ocean. This will provide an 

 intermediate step between conditions in the dry research chamber laboratories 

 and those in the open sea. 



