340 



H. M. POLLOCK, B. MALZBERG AND R. G. FULLER 



and sisters, of whom 4 developed psychoses. We may compare this with 

 a total of 1.8 expected cases. In view of the fact that the generation has 

 not yet completed its span of life, and that 2 brothers and 4 sisters show 

 signs of a psychopathic personality, we may reasonably expect additional 

 cases of mental disease in this group, thus indicating a probable significant 

 divergence between actual and expected findings. 



Tables 5 and 6 provide data concerning the families of the 95 female 

 manic-depressives. 



TABLE 6 



Classification of psychoses and other defects appearing among relatives of 95 female 



Of the 1558 known relatives of the female patients, no details were re- 

 corded in 135 cases, leaving 1423 individuals with recorded histories. There 

 were 40 cases of known mental disease giving a ratio of 2.8 per cent. This 

 is considerably in excess of the ratio found among the families of male 

 patients, but nevertheless, much less than the expected ratio. On the basis 

 of 4.7 per cent among males and 4.4 per cent among females, we would have 

 an expected total of 66 ± 5.3 cases. The number of actual cases therefore 

 falls with the limits of random sampling. The strictures with respect to 

 incompleted generations again apply, but, nevertheless, it is hardly likely 



