420 G. P. FRETS 



III. 64. They are brother's children; their fathers, 11.37 and 11.32 are 

 brothers. 



Of the children of III . 46 and III . 64 the three youngest died at an early 

 age. Of the three children who grew to be adults the second IV. 39 suffered 

 from manic-depressive psychosis, was treated many times in a clinic, and 

 finally committed suicide; the third, IV. 41, has the manic-depressive con- 

 stitution. 



IV. 39 is thus the probandus in our second case. Her psychosis is also 

 not the pure manic-depressive psychosis, but shows also characteristics of 

 dementia praecox. The study of heredity also here enables us to understand 

 the psychosis as a combined psychosis. 



The father, III . 46, is a brother of the father of probandus; thus the grand- 

 mother on the father's side was II. 18, who suffered from the manic-depres- 

 sive psychosis, and the grandfather was 11.37, who suffered from vecordia 

 (paranoia). 



The mother, III. 64, is a nervous, proud, more or less narrow-minded 

 woman. Her brother and sisters, III. 70; III. 64, and III. 67, show schi- 

 zoid features. The grandfather 11.32, on the mother's side of IV. 39 is, as 

 stated, a brother of the grandfather on the father's side (of IV. 39). 



On the father's side we find among the ancestors of IV 39 the manic-de- 

 pressive psychosis, the schizoid personality and vecordia (paranoia), on the 

 mother's side a second time schizoid features and vecordia. 



Both cases of psychoses quoted here show in the first place the significance 

 of heredity in general; we see in four successive generations the manic-de- 

 pressive psychosis appear; we see also the heredity of dementia praecox. 



In the second place, and that was the subject of my paper, the significance 

 is proved of the study of heredity for an insight into the construction of 

 psychoses; hence we see the quoted cases as examples of combined psychoses. 



