33 (Continued) 
Selected Stafr Members: 
A. K. Chizhov 
M. Ya. Kraft 
O. Yu. Magidson, Professor 
Ye. Ye. Mikhlina 
M. V. Rubtsov, Professor 
S. I. Sergiyevskaya 
M. N. Shehukina 
Yu. N. Sheynker 
L. N. Yakhontov 
V. G Yashunskiy 
Deseription: 
VNIKhFI is one of the leading pharmaceutical research institutes in 
the U.S.S.R. They not only engage in synthesizing new drugs and research on 
synthesis processes for diversified organic compounds, but also test com- 
pounds synthesized and developed by other institutes and groups for possible 
pharmacological use. They are also responsible for research and development 
on the problems of analytical control and quality standards of drug produc- 
tion in the chemical-pharmaceutical industry. 
Since 1944, they have conducted research on insecticides 
(especially those used in louse control), synthetic antisyphilitices, and 
estrogens. They have continuously worked on the extraction of alkaloids 
from plants and the definition of their structures; cocaine and quinine 
substitutes have been included in this work. tidotes for phenylnitrite 
poisoning, antibiotics for dysentery, and antimalarials are just a few of 
their developments. 
The synthesis procedures studied and perfected include those for 
basic organics, e.g., thiosemicarbazoles, sulfonamides, and organophosphorus 
and organometallic compounds, as well as for anesthetics and opiates such 
as anesthesin, novocain, and cocaine. 
The Institute has also developed specific drugs for the market-- 
"Dimedrol", an antihistamine with antianaphylactic and atropenilike effects 
and properties; "Tropacin", a spasmolytic for use to control disturbances 
due to diseases of the central nervous system; and "Ethoxyd", to aid in 
combatting tuberculosis. 
Their work on the toxicity, structure, and synthesis of polymeric 
arseno-compounds, especially Salvarsan, has received considerable 
recognition. 
For the past few years, several laboratories, including the 
Laboratory of Heterocyclic Compounds, the Analytical, and the Physics and 
Chemistry Laboratories have been investigating the tautomerism of certain 
hydroxy-, oxy-, and oxo-derivatives of heterocyclic compounds using spectro- 
scopic methods. They have also worked on the analysis of organic compounds 
using a nickel catalyst. 
