230 



SERUM ENZYME STUDY 



AUG. SEPT. 



30 31 I 2 3 4 5 6 7 8 9 10 I I 



TEAM I LDH -MEAN 



UPPER LIMIT 

 .NORMAL RANGE 





TEAM I 



SGPT - MEAN 



TEAM 



SGOT- MEAN 



PPER LIMIT 

 NORMAL RANGE 



/UPPER LIMIT 

 I NORMAL RAN( 



NGE 



Fig. 98. Sealab II, Team 1 serum enzyme 

 study (daily means) 



In general, the values obtained from subjects during the second week of exposure remained 

 on the high side of the mid-normal range. 



One subject (SC) studied in Team 1 was continued in the second team, and it is of interest 

 to note that during the second two-week exposure, all values were in normal limits. 



Serum Glutamic Pyruvic Transaminase (SGPT) 



Except for a very brief statement relative to a single above-normal finding for one subject 

 on day two, no other individual exceeded the upper limit. The SGPT values do appear to be in 

 the high normal range, and oddly enough, seem to bear an inverse relationship to LDH levels. 

 Low LDH levels, which appear around day nine, are paralleled by high SGPT levels. 



One member of Team 2 demonstrated an elevated SGPT which persisted for approximately 

 three days. On day four, this individual's SGPT fell to within normal ranges, and for the bal- 

 ance of the run approximated the trends shown in a plot of Team I's enzyme levels. 



Serum Glutamic Oxalacetic Transaminase (SGOT) 



Except for one subject from Team 1 who started with an elevated SGOT level which per- 

 sisted for five days, all values were within normal limits. The low SGPT level was noted on 

 day eight, one day preceding the high SGPT and low LDH levels. 



DISCUSSION 



The role of selected enzyme assay in the evaluation of physiological responses to environ- 

 mental stress is far from clear at this time. In addition, the intercorrelation of the enzymes 



