1891.] 



MICROSCOPICAL JOURNAL. 



75 



Further tests revealed the faqt that the new remedy begins to affect a 

 healthy adult only after the injection of the one-hundredth of a cubic 

 centimeter. But few persons are affected by a very slight fever, the 

 greater number being sensible-of only slight pains in the limbs and a 

 passing lassitude. 



Not so with healthy persons, or with those not suffering from tuber- 

 culosis. The reaction after the injection has an entirely different effect 

 upon those who are affected by tubercle-bacilli. Two distinct phe- 

 nomena become evident. 



First, a general reaction takes place upon the body. This reaction 

 makes itself known after the application of a small dose by a high fever, 

 together with a streaked exanthema upon the breast and neck. This 

 passes away in from 12 to 15 hours. In the second place, the parts in- 

 filtrated with tubercle-bacilli are affected by the destructive action of 

 the remedy. 



When the affected parts are visible to the eye, as in Lupus (phagen- 

 (lic rash), a tuberculous disease of the skin appearing in knots which 



"iG. 2. — B. Tuberculosis from Fresh Mucus (400 Dia.) 



Fig. 3. — B. Tuberculosis alter 14 Days. 



by and by wholly destroys parts of the skin, the progress of the action 

 can be exactly observed. The diseased parts then swell, become in- 

 flamed, and separate themselves from the healing skin, then change into 

 crusts or scabs, which after two or three weeks fall off, leaving a smooth 

 scar. 



The tubercle-bacilli are not killed by the new remedy (the lymph) , 

 but the tissues ira mediately surrounding the tubercle-bacilli are destroyed, 

 and are cast out of the organism as dead and useless parts. With the 

 dead tissues the tubercle-bacillus is expelled from the body. 



Where the diseased tissue is near the surface, as in the skin, the ex- 

 pulsion of diseased tissue is easily accomplished, but in the interior or- 

 gans the process is slower, and during the time of action the organism 

 is threatened by the danger of the still living bacilli passing from the 

 destroyed necrosed tissue into the healthy parts. The art of healing 

 must then come to the assistance of the body when necessary, and by 



