44 Narcotine, and Sulphate of Morphine. ee 
That narcotic, nervine, and stimulant operations, as here defined, 
are perfectly distinct operations, is abundantly proved, by the fact 
that there are numerous articles, which possess each individually, 
without any trace of the others; and the circumstance that two of 
these groups of effects, or even the whole three, are not unfrequently 
produced by the same articles, no more proves their identity, than 
the circumstance that Tobacco is both narcotic and cathartic, proves 
that these two effects are identical. 
RESULTS OF EXPERIMENTS WITH NARCOTINE. 
Ist. In the same quantities, Narcotine is far less operative upon 
the human system, than the Sulphate of Morphine, and even less 
so than Opium. . 
- Narcotine possesses the same degree of activity, when given 
pure and in substance, as in any other way tried, its virtues not being 
either enhanced or diminished by solution in oil, or in dilute Acetic 
acid. 
3d. From two to five grains of Narcotine appears to constitute 
a medium full dose, where only a single dose is to be taken, i. e. 
such a dose as will just fall short of producing any disagreeable ef- 
fects, in a person of ordinary susceptibility. 
4th. One grain of Narcotine appears to constitute a medium 
moderate dose, to be repeated at regular and short intervals ;—and 
three hours appear to constitute a medium suitable period of repeti- 
tion for such a dose, for a person of ordinary susceptibility. 
5th. Narcotine is slower, though it is less permanent in its ef 
fects, than the Sulphate of Morphine. The period required for 
the first manifestation of the several effects of Narcotine, is inter- 
mediate between that required for the effects of Sulphate of Mor- 
phine, and that required for the effects of Opium ; and the period of 
their duration is intermediate between that of the effects of Opium, 
and that of the effects of Sulphate of Morphine.* 
6th. Narcotine appears to be more or less nervine. The general 
nervine operation of Narcotine, I think is decidedly less than that 
produced by Sulphate of Morphine, but Iam not certain that it is 
less than that of Opium. Narcotine does not appear to produce any 
og a ies 
appe 
manures a 
tis remarkable that Morphine, which is much more speedy in its operation, 
‘ars to permanent in its effects even than Opium. 
