50 Narcotine, and Sulphate of Morphine. 
Bally says that the brain and nervous system are the parts of the ani- 
mal economy, upon which Morphine appears to exert its principal 
operation. This may be also true in general with the Sulphate; but, 
according to my observations, it would be very incorrect to under- 
stand it as excluding all effects upon the circulating, secretory, and 
absorbent systems. ‘The Sulphate of Morphine produces a very 
considerable degree of the calm, placid, and pleasurable sensation; 
the peculiar wakefulness, and even inability to sleep ; and the men- 
tal exhilaration, which constitute a nervine operation. Iam satisfied 
that its nervine effects are considerably greater, in comparison with 
its other operations, than the nervine effects of Opium. Whenever I 
have taken a single full dose of the Sulphate of Morphine, (which, 
with me, is about a quarter of a grain,) I have invariably been entire- 
ly unable to sleep, for a period between four and six hours after- 
wards. My wakefulness has always been calm, placid, and pleas- 
urable. Thus, when Ihave taken the dose, ths eginning of the 
evening, I have usually been kept awake by it, till about two o’clock 
the next morning, though the sleep obtained during the remainder of 
the time, has seemed to refresh me as much, as if I had slept the 
whole night. 
Sulphate of Morphine appears to possess more or less diaphoreti¢ 
power; though, as far as I am able to judge, less than Opium, and of 
course less than Narcotine. Sometimes‘also, it produces a trouble- 
some itching of the skin, which, in some cases, is universal, but in 
others, confined to the nose, the neck, the loins, and the inside of the 
thighs. According to Dr. Bally, this itching is occasionally, but rare- 
ly, accompanied with an eruption. 
In single full doses, the Sulphate of Morphine, under my observa- 
tion, has invariably produced more or less hoarseness. 
The Sulphate of Morphine powerfully allays morbid irritability 
and irritation,—morbid sensibility and sensation,—morbid mobility, 
restlessness, and jactitation, and irritative actions generally, provided 
they are connected with a non-phlogistic, or a positively atonic dia- 
thesis. This is substantially stated by Dr. Bally, though with less 
precision. He however asserts that this agent is incapable of allay- 
ing cough. . Now I have been long in the habit of using it, for this 
purpose, not only upon my patients, but upon myself, and I consider 
it as the most effectual article, in the whole Materia medica, perhaps 
with the exception of Narcotine only. 
The Sulphate of Morphine is speedily and powerfully anodyne; 
and I believe it is more so, in proportion to its soporific powers, that 
RNOLD, 
PURER ene 
all alte 
sonehiemeneictliaihia: 
