Narcotine, and Sulphate of Morphine. 55 
used the Acetate of Morphine, with good effect, in Dysentery, the 
pain and tenesmus were allayed, the complaint in some measure 
checked, and sleep was produced.” e adds, “I have however 
been considerably disappointed in another case, where effects were 
produced, which I must leave to Mr. Magendie to explain.” “I 
gave to a gentleman laboring under continued and troublesome gen- 
eral irritation of the system, half a grain of Acetate of Morphine, 
prepared by Messrs. Pelletier and Caventou.” ‘“ 'This dose was ta- 
ken at night, on going to bed, and in pill, but no sleep was produced ; 
there was great restlessness, a desire to rise, or as he expressed it, 
an inability to keep himself down, giddiness, partial delirium, and, 
in fact, all the symptoms of intoxication,” (an extremely inappropriate 
‘erm in application to these effects,) “from Opium, were produced.” 
“The next day, headache, heat of the palms of the hands, lassitude, 
and some febrile symptoms were the consequence.” ‘Three doses 
of Morphine of half a grain each, dissolved in Alcohol, it is said, - 
produced on Sertuerner, and three of his pupils, a decided stimulant 
effect, which was followed by prostration, numbness, and faintness. 
In one delicate individual, who swallowed vinegar, while in this con- 
dition, violent vomiting was immediately excited, which was followed 
by Profound sleep, and the next day, by headache, heaviness, ano- 
wexla, Nausea, retching, and torpor of the intestines. From suc 
observations as ] have been able to make, I am inclined to think that 
the quantity of Morphine which is required to relieve an extremely 
“vere degree of pain, is more likely to be followed by vertigo; 
Musea, faintness, vomiting, and headache, than the quantity of Opium, — 
oe be adequate to the production of the same anodyne - 
= : : ough perhaps my opportunities for determining this, a. 
Sulhane aoe extensive to enable me to decide. But, whether 
. Ae of Morphine produces disagreeable and unpleasant _—— 
‘nips “ppears to me to depend always upon the manner in whie 
ministered and managed, just as is the fact with Opium ; and 
ee: se — that such effects from either, depend upon a 
susceptibi Iclous management, in relation to the temperament, anc 
: = of the patient, and the circumstances of the disease. 
Morphin B y imagines that there is some reason to conclude that 
it hag sacks anthelmintic, because worms have been rejected, when 
niin, Sioned vomiting. Ihave known worms rejected by vom- 
I. "produced by the irritation of the fauces with a feather, but, 
Wt on that account, suspect that process of being anthelmintic. 
ve 
as 
