THE TREATMENT OF HOOKWORM INFESTATION WITH 

 CARBON TETRACHLORIDE 



A CLINICAL AND LABORATORY STUDY 



By Charles N. Leach 



Of the International Health Board 



Frank G. Haughwout 



Of the Bureau of Science, Manila 



and 



J. Earle Ash 



Major, Medical Corps, United States Army 



INTRODUCTION 



The work that forms the basis of this report was first under- 

 taken early in May, 1922, at a time when reports of a more or 

 less contradictory nature concerning the safety of carbon tetra- 

 chloride in the treatment of hookworm infestations in man 

 were being published from various parts of the world. Most 

 of these reports constituted the products of field work, by men 

 who had neither the opportunity nor the facilities for detailed 

 study, so we reached the conclusion that the time had arrived 

 for making a start toward the promulgation of a more precise 

 knowledge concerning the action of the drug. We early gained 

 the impression that many of the accidents that had occurred 

 might be traced to the use of an impure drug, so we determined 

 to study the action of the pure drug in as much detail as possible. 



The opportunity for doing this presented itself in Bilibid 

 Prison, in Manila, which has been the scene of many notable 

 studies in experimental medicine. The project was rendered 

 the more feasible by reason of the amiability with which the 

 average Filipino submits himself to reasonable experimentation. 

 We desire to record our appreciation of the willingness with 

 which our volunteer subjects entered into the work. 



Most of all, however, must we record our gratitude to Dr. 

 Henry Pick, chief of the prison sanitation division of the Phil- 



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