456 The Philippine Journal of Science 1923 



ippine Health Service and resident physician and surgeon at 

 the prison hospital, who really made it possible to carry out the 

 study successfully. Doctor Pick placed his hospital, laboratory, 

 and quarantine shed completely at our disposal, furnished us 

 with efficient attendants, and assisted us in many other ways. 

 We also must record our appreciation of the aid given us from 

 time to time by Mr. Philip Jones, chief inspector of the prison, 

 who facilitated our movements in the prison as a whole. In 

 addition to those specifically mentioned in various parts of the 

 paper, we desire to thank Maj. Harry A. Oliver and Capt. R. 

 C. Kirkwood of the United States Army Medical Corps, and 

 Dr. Hilario G. Lara of the Philippine Health Service, who gave 

 us incidental aid at times when one or another of us was tem- 

 porarily called to other duties. 



At the time the work was started we planned to make a study 

 of the elimination of the drug and had invited Mr. Albert H. 

 Wells, chief of the division of organic chemistry of the Bureau 

 of Science, to join us. Pressure of other work, however, pre- 

 vented us from carrying out this plan, which has been deferred 

 to a later date. 



We have reported on this work, which represents observa- 

 tions on one hundred men, in considerable length, because we 

 do not by any means consider that we have said the last word 

 on any of the themes we have discussed. We think it wise, 

 therefore, to give our findings in some detail in order that they 

 may be available to other workers who may desire to check or 

 criticise our report. 



It is now apparent that carbon tetrachloride as an anthelmin- 

 tic against hookworm possesses virtues that can be claimed by 

 no other drug of which we have knowledge; while we believe 

 it is safer than other drugs employed for the same purpose, we 

 feel that much remains to be added to our knowledge concerning 

 its pharmacology, and the extent and duration of pathological 

 effects it may sometimes bring about. Nevertheless, we feel 

 constrained to say that the trepidation we felt in the beginning 

 concerning the administration of the drug has been stilled as a 

 result of our observations. We still recall the half-hesitation, 

 in the face of adverse reports from other places, with which 

 we administered our first doses of 10 cubic centimeters, to three 

 condemned men. Since then we have felt no anxiety in ad- 

 ministering 12.5 and even 15 cubic centimeters, in selected cases. 



So far as concerns the toxicity of the drug we find ourselves 

 able, at the conclusion of the work, to state that not only did 



