Leach et al.: Hookworm Infestation 



The latter is shown 

 only in the larger vessels and can be accounted for by the method of death. 



Kidney. — Old process. There are a few hyaline masses representing 

 replaced glomeruli and a few of the glomeruli show beginning changes of 

 similar character. There is no change obvious except in and in the vicinity 

 of the glomeruli. 



Acute. — There is an engorgement of the veins and glomerular capillaries 

 with blood, some groups being much more intensely affected than others. 

 There has been some absorption of fluid in the epithelium of the glomeruli 

 and of the proximal convoluted tubules, but no change in staining reaction 



Impression. — Slight chronic glomerulonephritis. Acute passive conges- 



Photomicrographs of some of the sections studied by Major 

 Callender are shown on Plate 1. 



In their paper on the pathologic effects of carbon tetrachloride 

 on the human liver, Docherty and Burgess (2) proceed on the 

 basis afforded by the report of Smillie and Pessoa(9) who state 

 that small doses of carbon tetrachloride produced fatty degen- 

 eration of the liver and kidneys in dogs. 



Docherty and Burgess's experiments were made on three con- 

 demned prisoners in Ceylon. Two of these men received 5 cubic 

 centimeters of the drug in single doses while the third was 

 given a total of 8 cubic centimeters in two doses, the first of 5 

 cubic centimeters, and the second of 3 cubic centimeters, about 

 two weeks later. 



The first man was executed and went to autopsy six days 

 after treatment. Macroscopically the liver showed no evident 

 change. Microscopically there was "no well-defined change." 

 There was no evident macroscopic or microscopic change in the 

 kidney. 



The second man was executed two weeks after treatment. 

 Macroscopically, the liver was "slightly friable." Histologic 

 sections of the same organ showed "granular degeneration of 

 liver cells. Leucocytic infiltration." There was no evident 

 macroscopic change, and no definite microscopic change in the 

 kidney. 



The third man, who received a total of 8 cubic centimeters of 

 the drug, was executed eighteen days after treatment. Macros- 

 copically, his liver was found to be "very friable." Microscop- 

 ically, Docherty and Burgess report "Fatty degeneration of liver 

 cells. Diffuse leucocytic infiltration." The kidney in this sub- 

 ject showed no evident change, but microscopically there was 

 "cloudy swelling of proximal tubes." 



