4(58 The Philippine Journal of Science 1923 



on the administration of doses as low as 3 cubic centimeters, 

 and not a few have expressed serious doubts regarding the 

 safety of the drug. We never have administered a dose as 

 small as that to any adult, yet in no instance have symptoms 

 developed in our series that have given us the slightest cause 

 for anxiety. In another part of this paper we shall discuss 

 accidents that have happened to persons who were not under 

 our control. 



We are of the belief that the use of carbon tetrachloride 

 involves the exercise of the same medical knowledge and judg- 

 ment as are required in the administration of any other powerful 

 drug. We further believe that most instances in which unto- 

 ward symptoms supervene may be traced to either impurity 

 of the drug, alcoholism, or disease of the liver. We place these 

 factors in what we believe to be their order of usual occurrence. 

 While we do not criticize the product of any reputable drug 

 manufacturing house, we have from the beginning declined to 

 administer any carbon tetrachloride, no matter from what 

 source, until it has been assayed at the Bureau of Science. The 

 detection of the slightest impurity has invariably led to the 

 redistillation of the drug before its issuance. 



We do not wish to be understood as insisting on the adminis- 

 tration of carbon-tetrachloride in the comparatively massive 

 doses that we have used. Inspection of our tables will show 

 very clearly that it is quite possible to obtain satisfactory re- 

 sults on a milder basis. Lambert, (6) who has treated 20,000 

 subjects in Suva, Fiji, reports results that check almost iden- 

 tically with ours as regards the recovery of worms after treat- 

 ment. He administers 0.2 cubic centimeter of the drug per 

 year of age up to 15 years, giving a uniform dose of 3 cubic 

 centimeters thereafter, irrespective of age or weight. How- 

 ever, on the basis of these and the 25,000 other cases of our 

 own that we cite in this paper, we feel that we have definitely 

 proved that the fears expressed by other workers concerning 

 the toxicity of carbon tetrachloride are largely groundless. 



We have selected from our Bilibid group ten men who were 

 successfully treated on a basis of 1 cubic centimeter of the 

 drug to each 5.5 kilograms of body weight, and have arranged 

 them by weight according to our scale, and also by age, in 

 order to show what they would have received from us according 

 to our method and what they would have received by extend- 

 ing Lambert's age-dosage scale beyond 15 years. It will be 

 seen that only one man would have received a dose beyond the 



