23 ' 5 Leach et ah: Hookworm Infestation 459 



maximum given by us in this series— a man 70 years of age who 

 would have received 14 cubic centimeters, which dose we already 

 have exceeded by 1 cubic centimeter, with a man in another 

 series, without any ill effects. These figures are set forth in 

 Table 4. 



Table 4. — Comparative 



dosages of carbon 

 by body weight and 



tetrachloride as determined 



P„._ 



Weisht. 



tt,; 



Our 



cale. 



lee. to Age 



0.2 cc. 





| 



ii:i 



'?:i 



!:! 



85 26 



il 























The average dose of carbon tetrachloride administered to all 

 the men in the series was 8.96 cubic centimeters. The extremes 

 were 6.2 cubic centimeters and 12.5 cubic centimeters, the latter 

 dose having been administered to two men. 



Relatively few men escaped some reaction to the drug. The 

 usual symptoms (those we have arbitrarily characterized as 

 "normal") consisted of vertigo and drowsiness. The majority 

 of the men passed into a quiet sleep from which it was not 

 especially difficult to rouse them, within fifteen or twenty 

 minutes after^they had taken the drug. This sleep rarely lasted 

 more than an hour or two. Usually most of the men in the 

 different squads were awake when their pulses and blood pres- 

 sures were taken one hour after treatment, but they usually 

 were quite content to lie still for another hour. Some of the 

 men spoke of vague sensations in the abdomen which we are 

 inclined to regard as the expression of rather vigorous peris- 

 taltic movements of the intestine. 



Bowel movements, as a rule, began about one to two hours 

 after treatment, and the bowels moved several times within 

 the next twenty-four hours. There was a return to normal 



