470 The Philippine Journal of Science 1923 



consistence of the stool by the end of the first day following 

 treatment. The first bowel movements were not accompanied 

 by any disturbance, but after two to three hours the drug was 

 prone to leave the intestine in one gush, which occasioned great 

 surprise and some momentary discomfort to the patient. 



Occasionally, as a departure from what we have styled the 

 "normal," patients would complain of nausea and vomiting, or 

 excessive thirst, or anorexia, or weakness. Exceptionally, 

 there was abdominal pain, or continued vomiting, or both. 

 Vomiting occurred only in subjects who received 8 cubic cen- 

 timeters of the drug or more. Only two patients became 

 constipated during treatment. ThCy each were given mag- 

 nesium sulphate the day following treatment and apparently 

 experienced no ill effects from the prolonged retention of the 

 drug. 



At this time it seems appropriate to say something concern- 

 ing the general hepatic and intestinal reaction to the drug as 

 evidenced by the appearance of the bowel contents after treat- 

 ment. This bears particularly upon the appearance of bile 

 and mucus in the stools. The detailed observations are recorded 

 in Table 10, which must be consulted for information as to 

 the findings in the individual subjects. 



As we have shown elsewhere, carbon tetrachloride exerts a 

 definite stimulating influence upon the liver, and markedly 

 increases the volume of bile discharged into the intestine. Its 

 effects as a cholagogue may be apparent up to the third day 

 after treatment, but as a general rule the bile content of the 

 stool tends to return to normal after the first twenty-four hours. 

 Stools passed after treatment usually are watery after the 

 contents of the lower bowel have been evacuated. The watery 

 fluid is charged with greater or lesser amounts of bile. Usually, 

 this is dark brown in color, but occasionally stools are passed 

 that are of a brilliant green hue and, if mixed witk considerable 

 mucus, bear a resemblance to stools passed by young children 

 who are suffering from disorders of the intestinal tract. We 

 have been unable to determine that an excessive bile content 

 to the stool is associated with any particular symptom or tram 

 of symptoms in the subject. We have given carbon tetrachlo- 

 ride to one subject who was jaundiced before treatment, and 

 also have administered it in several cases in which there was 

 definite enlargement of the liver (presumably of malarial ori- 

 gin) without noting any symptoms referable to the liver. In 

 i has a subject complained of pain or even discomfort 



