Leach et al.: Hookworm Infestation 



475 



ment. Eleven exhibited pulmonary disturbances, mainly of a 

 tuberculous nature. There were also some who showed enlarge- 

 ment of the liver or spleen or both, probably of malarial origin. 

 There were some disturbances of the urinary system, some val- 

 vular heart lesions, hernias, and the like. Only one or two 

 were frankly .sick. 



Briefly, it may be stated that none of these men showed any 

 reaction to the drug that differed in any essential form or degree 

 from that shown by men in whom no pathology was detected. 

 Of men showing enlargement of the liver only one was jaun- 

 diced, and he suffered no untoward effects from the drug. We 

 were able to detect no influence of the drug on men suffering 

 from valvular disease of the heart or any of the other cardiac 

 irregularities detected by us. All of these cases were studied 

 with particular care. As a matter of fact, twenty-two of 

 these men gave no evidence of any general reaction to the drug. 



During treatment of these men, there was a fall in pulse rate 

 in all except two cases, the range being from 6 to 66 beats a 

 minute. The 66-beat fall was due, in all probability, to excite- 

 ment in the original examination, there being a fall from 130 

 beats on that occasion to 64 at the time of treatment. There 

 was another, a nonpathologic case, with a pulse rate of 162 at 

 physical examination and 98 on treatment. Neither of these 

 men gave any evidence of cardiac trouble. 



Nothing significant was shown by the blood or pulse pres- 

 sures in these cases. The observations on these men are re- 

 corded in Table 7. 



Table l.—Observatic 



ns on subjects s 



howing -physical defects. 



.£_ 



Physical defect. 



B. 



J3E 



«-. 



«-&— 



— -■ 



,3,12 



Active tubercu- 



8.7 



-M 



Nom * 1 



Hyaline caste 



Norma!. 



!;:* 



Liver palpable... 



8.8 



I*. 



"M.-,b».: 





S: 



14670 



Hydrocele; her- 



8.5 



-u 



-:;;.. 





hemoptysis. 



