23,6 Leach et al.: Hookworm Infestation 483 



To begin : The first group of twenty-five subjects, having an 

 average weight of 54.5 kilograms, received an average dose of 

 carbon tetrachloride amounting to 7.7 cubic centimeters, cal- 

 culated on a basis of 1 cubic centimeter of the drug to each 7 

 kilograms of body weight. None of the men in this group 

 vomited. In fact, only two men showed reactions barely over 

 the threshold of those we have arbitrarily designated as 

 "normal." On a liberal interpretation, therefore, we state that 

 4 per cent of the men in this group showed slightly unpleasant 

 symptoms. 



The second group of men, nine in number, of an average 

 weight of 51.3 kilograms, received an average dose of 7.8 kilo- 

 grams of carbon tetrachloride, calculated on a basis of 1 cubic 

 centimeter of the drug to each 6.5 kilograms of body weight. 

 By referring to Table 9, it will be seen that the average dose 

 and the range of dose show very little variation over those of 

 the preceding group, which taken with the numerical strength 

 of the group makes clear the fallacy involved in the 22 per cent 

 abnormal reactions we are forced to charge against the two 

 men who vomited after treatment. 



A more satisfactory basis of calculation is afforded by the 

 third group. This consisted of twenty-nine men, whose average 

 weight was 55 kilograms, and who received an average dose of 

 9.1 cubic centimeters of carbon tetrachloride, calculated on a 

 basis of 1 cubic centimeter of the drug to each 6 kilograms of 

 body weight. Six of these men were sick after treatment, but 

 we feel that only four of the reactions should be charged against 

 the drug. Two of the men passed stools that contained blood, 

 pus, and mucus thirty-six hours after treatment, at which time 

 they had wholly recovered from the very slight reaction they 

 exhibited to the drug. On careful study of stained preparations 

 made from these stools, we are convinced that these two men 

 suffered a slight exacerbation of bacillary dysentery which bore 

 no direct relation, at least, to the treatment. The other four 

 men had vomiting of varying degrees of severity probably 

 largely the result of eating too heavy a meal four or five hours 

 after the drug was administered, but exhibited no other ill 

 effects. Therefore, we record 14 per cent of symptoms above 

 our normal in this group. 



The fourth and final group consisted of thirty-seven men ; but, 

 as the records are imperfect in certain particulars in four in- 

 stances, we have figured on a basis of thirty-three men. The 

 average weight of the men in this group was 55 kilograms, 



