516 The Philippine Journal of Science ms 



out a series of observations with this end in mind. The work 

 done and the results obtained are set forth here. 



TREATMENT GROUPS 



For our purpose one hundred ninety-four patients of both 

 sexes and of varying ages were selected. All had been treated 

 for nearly a year, in different groups, all receiving for the last 

 few months the plain (noniodized) chaulmoogra ethyl esters, 

 and from all appearances they had improved to a greater or less 

 extent as a result of the treatment. 



The patients were divided into four main groups, an attempt 

 being made to make these uniform so far as sex and age were 

 concerned. The type and the duration of the disease and the 

 extent of involvement of the tissues differed so widely that it 

 was not considered advantageous to attempt to determine the 

 groups on this basis. The cases were practically all of the 

 cutaneous and mixed types, and moderately advanced, though on 

 the average not to the point of being distinctly unfavorable for 

 treatment. Each of us treated approximately one-half of each 

 group, more or less independently. 



The observation, at the time the data herein presented were 

 obtained, had extended over a period of six months. Injections 

 were given intramuscularly twice a week, except when for some 

 reason or other injection was postponed. 



The treatments used were* as shown in Table 1. 

 Table 1. — Treatments iised. 



Group I, in which there was no change from the treatment 

 previously given to all, served as the control. Group II was 

 treated identically except that a pill containing 0.3 milliliter of 

 creosote was given at each injection, totaling 0.6 milliliter of this 

 drug per week when the patient took both treatments. The dose 

 was made small in the desire to avoid gastric irritation. Group 

 III was given injections of a solution with the formula chaul- 

 moogra ethyl esters, 1,000 milliliters; creosote, 25 milliliters; 

 camphor, 25 grams. The solution given Group IV differed from 

 this in that no camphor was used and, after the first few injec- 



