23,5 Samson and Limkako: Creosote in Leprosy 517 



tions, but 12.5 milliliters of creosote to 100 milliliters of the 

 ethyl esters. The ordinary United States Pharmacopoeia grade 

 of creosote was used almost entirely on account of the cost of 

 the beechwood variety. 



DOSAGE 



As all of the patients were accustomed to receiving injections 

 of the plain ethyl esters, the dosage that it was found possible to 

 give the different groups is a fair indicator of the irritation, local 

 or distant, produced by each particular preparation. 



In establishing the maximum tolerated dose the drug was 

 pushed, being increased by 1 milliliter at a step to the point of 

 production of untoward effects, either local or general ; the next 

 lower milliliter was taken as the amount tolerated by that 

 patient. We have observed that on attempting subsequently to 

 increase the dose beyond this point unfavorable effects were 

 usually produced. 



TABLE 2. — Maximum tolerated dose of creosote. 



r : ~ 





Percental receivin,- 







lee. 1 2cc. I 8cc. | 4cc. 1 5cc. 





i 



a J ;;::! s| s 

 ,.:| s| s| ~| ■: 



: .:. 



The data given in Table 2 are plotted in fig. 1. 



The similarity of the curves of Groups I and II, which received 

 injections of plain esters, is striking, as is that of the curves 

 of Groups III and IV, which received creosote-ester solutions. 

 The difference between these two pairs of curves is of interest. 

 From the dosage figures of Table 2 the following averages are 

 obtained : Groups I and II, 3.8 and 3.7 milliliters, respectively ; 

 Groups III and IV, 3.1 and 3.2 milliliters. 



Naturally, creosote taken by mouth in small doses (Group 

 II) does not influence the total amount of the ethyl esters that 

 can be given intramuscularly. On the other hand, it is ap- 

 parent that the incorporation of creosote in the ethyl esters, at 

 least in the concentrations used, does lessen the amount of the 

 mixture that can be given without undesirable effects. 



It is of interest that Group III could be given practically as 

 large doses of the creosote-camphor solution (20 per cent of 

 each) as could Group IV with approximately 11 per cent creo- 



