f>18 



The Philippine Journal of Science 



sote and no camphor. At the outset 20 per cent creosote with- 

 out camphor was used in Group IV, but this was so irritating 

 that the amount added to the 100 milliliters of ethyl esters was 

 reduced to 10 cubic centimeters. The patients complained of 

 pain during injection, and serious local inflammations devel- 

 oped subsequently. Therefore, it is clear that camphor in this 

 combination does reduce irritation. 



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The matter of dosage is distinctly affected by the personal 

 equation of the physician. For example, one of us reached a 

 maximum dose of 4 milliliters in 91 per cent of his plain ethyl 

 ester groups, the other in but 53 per cent. On the other hand, 

 the first reached this dose in but one of his forty-seven cases 

 receiving creosoted preparations (2.1 per cent), and the other 

 in 49 per cent of forty-five patients. 



