526 The Philippine Journal of Science 1923 



absences. In Group III, with the 20 per cent solution in chaul- 

 moogra ethyl ester, 0.6 milliliter of creosote was injected in 

 each average dose of the mixture, 3 cubic centimeters, or at 

 most 30 grams of creosote in the six months. In Group IV with 

 which almost a 10 per cent solution was used, practically one- 

 half of this total amount, 15 grams, would be given. 



Here are seen two interesting contrasts; namely, between the 

 same amount of creosote given by different routes and different 

 amounts given by the same route. In Group II, 0.6 gram per 

 week was given by mouth. The chief result, so far as was 

 observed, was apparent stimulation of appetite, increase of 

 weight, and generally improved condition, with at the end better 

 figures for improvement than in the control group. In Group 

 IV the same amount of creosote per week was given intramus- 

 cularly. The improvement, betterment of the general condition 

 so noticeable in the second group, was not so marked, but the 

 first figures on improvement of the disease are the best of the 

 series, decidedly better than for Group II, in spite of the fact 

 that the amount of chaulmoogra given was less. 



In contrast with the last group is Group III, which received 

 by the same route 1.2 milliliters of creosote per week, together 

 with 1.2 grams of camphor. Here the improvement rate is 

 practically the same as in Group II, and the worse rate is by 

 far the highest of the series. Why this preparation should 

 give poorer results than in Group IV is not clearly apparent. 

 While there may possibly be an element of fortuity, this is be- 

 lieved not determinative. It seems improbable that a 0.6 gram 

 dose of creosote given twice a week is excessive, even by the 

 route used, though we know of no data on the intramuscular 

 use of this drug. It has been suggested to us that the camphor, 

 which is not a drug that one would naturally use in such a 

 disease in considerable dosage over a long period, may be re- 

 sponsible for these less favorable results. 



A sidelight on the results of the treatment is given by the 

 effects on the weight of the patients. The changes that have 

 occurred between September, 1922, and January 15, 1923, are 

 shown in Table 9. 



Most of the control group, Group I, gained weight, but Group 

 II showed a higher percentage, 78 against 67. Those receiving 

 creosote by injection gave lower percentages than either Group 

 I or Group II. Group III, with the lowest improvement and 

 highest worse rate, reflects these results in the weight changes. 



