578 The PhMPP ine Journal of Science 1923 



to three days. After six such injections of 1.5 milliliters he began to have 

 persistent abdominal pain, diarrhoea, prostration, and finally passed blood 

 per rectum. Injections were suspended and the diarrhoea disappeared 



^clTe J J -P h c. r AfteTthe first two injections the ulcers began to heal, 

 but on increasing the dose to 2.5 milliliters they began to break out again, 

 and albumin appeared in the urine. After a brief rest the injections 

 of 1 5 milliliters were resumed and the ulcers again improved. The injec- 

 tions were then given every three days. After six injections the patient 

 became very weak, the old ulcers broke out afresh all over the body, and 

 a large one appeared in the larynx, which made swallowing very dif- 

 ficult The drug was discontinued and the ulcers improved, but that of 

 the larynx persisted and the patient died in less than a month. Au- 

 topsy was not performed. 



As a result of these experiences the dose usually given there- 

 after was 1.5 milliliters per week, though in some cases it was 

 occasionally increased to 2 milliliters. 



RESULTS OP TREATMENT 



Of the thirty cases of leprosy put under treatment, five died 

 before the end of the experiment, that is, within six months. 

 Another died two weeks after its conclusion; in the discussion 

 below this case is not included among those surviving at the 

 end of the experiment. The mortality during the experimental 

 period was, therefore, 16.1 per cent; the sixth death brings 

 it up to 19.3 per cent. The results obtained in the survivors are 

 shown in Table 3. 



Table 3.— Results of treatment in the twenty-four surviving cases. 





i ,,-ral 





UlcerJ 





i 









Tot 1 



,4 



24 | 24 









General condition.— The results, so far as the general condi- 

 tion is concerned, are quite unsatisfactory. Not only did none 

 of the survivors show much improvement, but a large proportion 

 of them became worse during the experiment. 



Leprotic lesions.— No improvement whatever could be seen in 

 the leprotic lesions. No case in the series became bacteriolo- 

 gically negative. 



